She has now won 32 Grammys throughout her career.
The record was previously held by Hungarian-British conductor Georg Solti, who has 31 Grammys, since 1997.
Beyonce already holds the title of most Grammys won by a female artist.
Viola Davis achieves EGOT status
Another big winner for the night was actor Viola Davis, who has become the latest star to earn a coveted EGOT — a combination of an Emmy, a Grammy, an Oscar and a Tony.
Davis completed her EGOT status by winning the Grammy for best audio book, narration and storytelling for her memoir "Finding Me."
"I wrote this book to honor the 6-year-old Viola, to honor her, to honor her life, her joy, her trauma, her everything," the actor said as she accepted her award.
Davis is the third Black woman to achieve EGOT status, and the 18th person overall.
Album of the year: Harry's House
With his album "Harry's House," British singer Harry Styles won the night's top gong: album of the year.
He came out atop some of the biggest names in music from pop, rap, rock and R&B, including Beyonce, Adele and Kendrick Lamar.
"This doesn't happen to people like me very often, and this is so nice," he said onstage.
