State officials said search and rescue efforts continued.
In Alabama, where the tornado hit next as it began to dissipate, the sheriff's office in Morgan County said one man had died after being trapped when a trailer flipped over.
Mississippi was also bracing for more turbulent weather on Sunday, including high winds and hail, with the state's emergency management agency warning that "tornadoes cannot be ruled out."
The tracking website poweroutage.us reported late on Saturday that roughly 4,800 customers were still without power in Mississippi, as supplies were restored in several areas, and nearly 11,000 homes and business were in the dark in Alabama.
What happened with the tornado?
The National Weather Service confirmed a tornado caused damage about 60 miles (roughly 95 kilometers) northeast of Jackson.
The rural towns of Silver City and Rolling Fork reported destruction as the tornado swept northeast at 70 miles per hour without weakening, racing towards Alabama through towns, including Winona and Amory, into the night.
Entire buildings were left in rubble and cars flipped on their sides as people climbed through the debris in the dark.
A tornado has touched down in Silver City, MS, in Humphreys County. Highway 49W is congested at this time with emergency crews. Please use an alternate route if possible. pic.twitter.com/npfYxnMGSN
Governor Tate Reeves said authorities deployed ambulances, medical support and emergency assets for those affected.
"Many in the MS Delta need your prayer and God’s protection tonight," he said.
The National Weather Service issued an alert which read: "To protect your life, TAKE COVER NOW!"
It warned residents they were in a "life-threatening situation."
"Flying debris may be deadly to those caught without shelter. Mobile homes will be destroyed. Considerable damage to homes, businesses, and vehicles is likely and complete destruction is possible."
