The incident appears to have been the result of an accident and there are no known fatalities.
Mayor Giuseppe Sala told reporters the van where the blast originated was carrying oxygen cylinders and that the explosion was not due to terrorism or crime.
Italy's Corriere Della Sera newspaper cited a witness saying the vehicle was carrying oxygen cylinders. Passers-by said there had been a fire followed by a very strong explosion.
As well as engulfing several cars, the newspaper said the fire that took hold subsequently had damaged a nearby pharmacy and apartments in a nearby building.
The driver of the van carrying the cylinders was said to have jumped out of the vehicle in time after noticing the fire, sustaining injuries to his hand and leg.
The Reuters news agency said that one person had been injured in the blast, but that there were no known fatalities.