The Birmingham contest will be Harry Brook's first outing as England's ODI captain and the newly-appointed skipper will bat at No.4 in a side that looks remarkably different to the one that appeared at the ICC Champions Trophy event in February and March this year.
Pacers Jofra Archer and Mark Wood miss through injury, Phil Salt and Liam Livingstone are omitted and Brook takes over from long-time captain Jos Buttler as the captain.
Buttler remains in the XI and will bat at No.5 and keep wickets, while fellow keeper Jamie Smith is promoted to the top of the order and open the batting alongside consistent left-hander Ben Duckett.
There is also room in the XI for youngster Jacob Bethell and fit-again pacer Brydon Carse, while
star spinner Adil Rashid will headline the bowling attack that includes Saqib Mahmood and Jamie Overton.
The three-match series is crucial for England as they look to build momentum in 50-over cricket ahead of the next ICC Men's Cricket World Cup in South Africa, Zimbabwe and Namibia, with the side currently ranked in eighth place on the ICC ODI Team Rankings and in the final direct
qualifying position for the 2027 tournament, an ICC report said.
Brook is aiming to help his side find their rhythm against the West Indies and move up the rankings prior to the event.
"New era now, new leadership. Hopefully we can bring a lot of energy, competitiveness, and a lot of fun as well out there, try and engage the fans as much as we can - and yeah, try and get some wins under our belt," Brook said.(UNI)
England XI: 1. Jamie Smith, 2. Ben Duckett, 3. Joe Root, 4. Harry Brook (c), 5. Jos Buttler (wk), 6. Jacob Bethell, 7. Will Jacks, 8. Jamie Overton, 9. Brydon Carse, 10 Adil Rashid, 11. Saqib Mahmood.