Holder didn't bowl when his team fielded in the second innings and wasn't required to bat on the final day of the three-day warm-up match on Thursday.
"Jason has had a slight niggle on his ankle and that is what has held him back from bowling," Simmons was quoted as saying by the windiescricket.com.
"He will be back to bowling in the four-day game and should be bowling his full quota. As for the batting if you get one ball and you're out, that's all you can do," he added.
West Indies will have a four-day warm-up match starting June 30 at Emirates Old Trafford, before they travel down to Southampton for the first match at the Ageas Bowl, starting July 8.
Simmons also spoke about the fitness of experienced fast bowler Shannon Gabriel, who is making a return from ankle surgery.
"He looks ready, that was evident here. When you see how he bowled in the first innings, then again yesterday and even more so this morning you could see he's close to 100 percent. Now we want to get him up to 100 just before the Test match," he said.(UNI)
