Notching up a la Brian Lara knock, Prakhar belted 46 boundaries and 3 sixes as Karnataka declared their innings at 890/8 at the KSCA Navule Stadium here on Monday.
During the historic knock, he raced past Yuvraj Singh's 358 runs record in the finals of this prestigious tournament.
However, Vijay Zol's unbeaten 451 for Maharashtra against Assam in the 2011-12 season remains the highest individual score in the league stages of the tournament.
The quadruple century helped Karnataka bat Mumbai out of the contest by winning the title clash based on a first-innings lead. Karnataka had whittled out Mumbai for 380 all out on Day 2 of the match.
This feat could also get him a Ranji berth, especially after Karnataka's ignominious loss to Gujarat who bundled them out for 103, chasing a 110-run target on Day 4 of the match held at Narendra Modi Stadium in Ahmedabad.