Vatican police fired at the speeding car's front tires after it rushed the gate, but the vehicle managed to continue on its way, the Vatican press office said in a statement.
When the car reached the San Damaso Courtyard of the Apostolic Palace, the driver got out and was arrested by Vatican gendarmes.
The incident took place at around 8 p.m. local time (1800 UTC/GMT) at the Santa Anna Gate, which is one of several main entrances to the 108-acre sovereign Vatican City State in Rome.
A rare incident
Much of the Vatican City State is off limits to the general public — especially at night.
While the incident marked a rare incursion, it was not the first time a seemingly psychologically disturbed person caused disruption in the city-state.